Visible-Light-Promoted Histidine-Specific Peptide C-H Alkylation
نویسندگان
چکیده
منابع مشابه
Visible Light Promoted Allylic C–H Oxidation
A mild and efficient one-pot visible light-induced method has been developed for the allylic oxidation. The oxidation of allylic systems has played a prominent role in this context as possibly the most widely applied C–H functionalization, owing to the utility of enones. The allylic C–H oxidation is relatively simple and predictable, even on a preparative scale, because active species generated...
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9-Methylacridine was identified as a generally effective ligand to promote a Pd(II)-catalyzed C(sp(3))-H and C(sp(2))-H alkylation of simple amides with various alkyl iodides. This alkylation reaction was applied to the preparation of unnatural amino acids and geometrically controlled tri- and tetrasubstituted acrylic acids.
متن کاملVisible light-promoted metal-free C-H activation: diarylketone-catalyzed selective benzylic mono- and difluorination.
We report herein an operationally simple method for the direct conversion of benzylic C-H groups to C-F. We show that visible light can activate diarylketones to abstract a benzylic hydrogen atom selectively. Adding a fluorine radical donor yields the benzylic fluoride and regenerates the catalyst. The selective formation of mono- and difluorination products can be achieved by catalyst control....
متن کاملVisible-light-promoted stereoselective alkylation by combining heterogeneous photocatalysis with organocatalysis.
The application of sensitizers to utilize visible light for chemical reactions is an established method. Several recent publications have impressively demonstrated the versatile use of visible light for various transformations, such as the conversion of alcohols to alkyl halides, and [2+2], [3+2], and [4+2] cycloadditions as well as carbon– carbon and carbon–heteroatom bond formations. The comb...
متن کاملVisible light C-H amidation of heteroarenes with benzoyl azides.
Benzoyl azides were used for the direct and atom economic C-H amidation of electron rich heteroarenes in the presence of phosphoric acid, a photocatalyst and visible light. Hetero-aromatic amides are obtained in good yields at very mild reaction conditions with dinitrogen as the only by-product. The reaction allows the use of aryl-, heteroaryl- or alkenyl acyl azides and has a wide scope for he...
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ژورنال
عنوان ژورنال: Chinese Journal of Organic Chemistry
سال: 2019
ISSN: 0253-2786
DOI: 10.6023/cjoc201900010